Clinton County, a rural community in New York State, facilitated the implementation of an Overdose Fatality Review (OFR) to strengthen its overdose prevention efforts. OFRs are invaluable tools to identify systemic gaps, foster collaboration among partners and develop actionable strategies to prevent future overdoses. However, in a close-knit community with a relatively low number of overdose fatalities, privacy concerns and the absence of state-specific OFR legislation present implementation challenges.