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The 2025 ORS Annual Report is now available!
In this latest report, learn more about the overdose landscape in 2025 and how the ORS has adapted to meet new and evolving challenges. Learn how the ORS has expanded its reach across the nation by building stronger partnerships with overdose prevention organizations and how ORS teams help communities by using data, improving access to policy information and bringing different sectors together to strengthen overdose prevention and response efforts.
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ONDCP and CDC Highlight the Critical Role of the Overdose Response Strategy
In a joint statement released by the White House, the Centers for Disease Control and Prevention (CDC) and the Office of National Drug Control Policy (ONDCP) recognized the Overdose Response Strategy (ORS) as the only national program specifically designed to strengthen overdose prevention through coordinated public health and public safety partnerships.
Read the full statement here     →
ORS Teams Strengthen Overdose Readiness for the 2026 FIFA World Cup
The 2026 FIFA World Cup brought international visitors to host cities and surrounding communities across the United States, creating opportunities to share information about overdose risks and response.
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Alaska ORS Team Assists with Next Move Educational Campaign for Youth
Young adulthood is a pivotal window for substance use prevention. National Survey on Drug Use and Health data from 2023 show that alcohol and marijuana use often begins at younger ages, while opioids, stimulants and hallucinogen use typically begin around age 21. Ages 18–25 represent a period of major life transitions, when stress, peer influence and new independence can influence substance use.
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Expanding Access: Bringing Naloxone to Underserved Communities
Across rural and underserved areas of Texas, geographic distance, limited pharmacy access, cost and misconceptions can make naloxone and other overdose prevention resources difficult to access for people at highest risk of opioid overdose. While communities and campuses were often willing to help, they did not always know where to obtain naloxone or have the partnerships needed to bring it to their communities.
Read More     →
ORS Trends, Analysis & Threats Webinar
Join the ORS for a bi-monthly webinar series delivering briefings on current and emerging drug trends from experts with leading forensic and toxicology labs. Click the link below to register and view upcoming dates.

Date: First Wednesday, every other month
Time: 2:00-3:00 PM EST
REGISTER HERE

A public health and public safety program

The Overdose Response Strategy (ORS) is an unprecedented and unique public health-public safety partnership between the Office of National Drug Control Policy (ONDCP) and the U.S. Centers for Disease Control and Prevention (CDC) through their support of the High Intensity Drug Trafficking Areas (HIDTA) program and the CDC Foundation. At its core, the ORS is an example of a cross-agency, interdisciplinary collaboration with a single mission of reducing overdose deaths and saving lives across the United States.

WHO WE ARE

OUR HISTORY

The ORS, a partnership between CDC and ONDCP, with support from HIDTA and the CDC Foundation, has grown significantly since its launch. The program began in 2015 with only five originating HIDTAs, covering 15 states. Today, the program includes all 33 HIDTAs, covering all 50 states, the District of Columbia (DC), Puerto Rico and the U.S. Virgin Islands.

When public health and public safety—each bringing distinct perspectives and expertise—work together toward a shared goal, the impact is profound.

“The Overdose Response Strategy demonstrates the power of partnership and the strength of a truly integrated national network. When public health and public safety—each bringing distinct perspectives and expertise—work together toward a shared goal, the impact is profound. The ORS continues to evolve by connecting partners, sharing information, and turning collaboration into action.” Chauncey Parker, Director, New York/New Jersey HIDTA

WHAT WE DO

annual report

The ORS Annual Report provides an overview of the current state of the overdose epidemic and highlights the program’s key strategies and accomplishments in 2025. Click the link below to learn more about ORS teams, their impact and the success stories that demonstrate their continued commitment to this work.

ORS Stories and News

The construction industry faces significant overdose risks, as workers may experience job-related injuries and seek opioids to manage pain while continuing to work. Concerns about reporting workplace injuries, including

A gap in naloxone access can result in a missed opportunity to reduce the risk of a subsequent overdose. The Indiana Overdose Response Strategy (ORS) team identified that a

The 2026 FIFA World Cup brought international visitors to host cities and surrounding communities across the United States, creating opportunities to share information about overdose risks and response. The

In a joint statement released by the White House, the Centers for Disease Control and Prevention (CDC) and the Office of National Drug Control Policy (ONDCP) recognized the Overdose

Share & Connect. Collaborate. Inform & Promote. Help & Implement.