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ONDCP and CDC Highlight the Critical Role of the Overdose Response Strategy
In a joint statement released by the White House, the Centers for Disease Control and Prevention (CDC) and the Office of National Drug Control Policy (ONDCP) recognized the Overdose Response Strategy (ORS) as the only national program specifically designed to strengthen overdose prevention through coordinated public health and public safety partnerships.
Read the full statement here     →
PR ORS Team Training in Caguas Leads to Life Saving Overdose Intervention
In May 2026, as part of a collaborative public health and public safety initiative, the Puerto Rico Overdose Response Strategy (ORS) team delivered specialized opioid overdose recognition and response training to 36 officers from the Caguas Municipal Police Department.
Read More     →
WI ORS Team and the Wisconsin Department of Health Services Host Five Overdose Prevention Summits for First Responders
First responders play a critical role in overdose response, yet they may have limited opportunities to connect across agencies and share strategies. To address this gap, the Wisconsin Overdose Response Strategy (ORS) Public Health Analyst (PHA) and the Wisconsin Department of Health Services (DHS) hosted the first annual Overdose Prevention Summits for First Responders in April 2026.
Read More     →
ORS and ASTHO Advance Overdose Spike Response Preparedness Across States
In 2025, Overdose Response Strategy (ORS) teams in multiple states partnered with the Association of State and Territorial Health Officials (ASTHO) to strengthen overdose spike preparedness through the Overdose Spike Exercise-in-a-Box Toolkit pilot program.
Read More     →
The 2025 ORS Annual Report is coming soon!
In this latest report, learn about the overdose landscape in 2025 and how the ORS has adapted to meet new and evolving challenges. Learn how the ORS has expanded its reach across the nation by building stronger partnerships with overdose prevention organizations and how ORS teams help communities by using data, improving access to policy information and bringing different sectors together to strengthen overdose prevention and response efforts. More information forthcoming!
View all reports
ORS Trends, Analysis & Threats Webinar
Join the ORS for a bi-monthly webinar series delivering briefings on current and emerging drug trends from experts with leading forensic and toxicology labs. Click the link below to register and view upcoming dates.

Date: First Wednesday, every other month
Time: 2:00-3:00 PM EST
REGISTER HERE

A public health and public safety program

The Overdose Response Strategy (ORS) is an unprecedented and unique public health-public safety partnership between the Office of National Drug Control Policy (ONDCP) and the U.S. Centers for Disease Control and Prevention (CDC) through their support of the High Intensity Drug Trafficking Areas (HIDTA) program and the CDC Foundation. At its core, the ORS is an example of a cross-agency, interdisciplinary collaboration with a single mission of reducing overdose deaths and saving lives across the United States.

WHO WE ARE

OUR HISTORY

The ORS, a partnership between CDC and ONDCP, with support from HIDTA and the CDC Foundation, has grown significantly since its launch. The program began in 2015 with only five originating HIDTAs, covering 15 states. Today, the program includes all 33 HIDTAs, covering all 50 states, the District of Columbia (DC), Puerto Rico and the U.S. Virgin Islands.

When public health and public safety—each bringing distinct perspectives and expertise—work together toward a shared goal, the impact is profound.

“The Overdose Response Strategy demonstrates the power of partnership and the strength of a truly integrated national network. When public health and public safety—each bringing distinct perspectives and expertise—work together toward a shared goal, the impact is profound.   The ORS continues to evolve by connecting partners, sharing information, and turning collaboration into action.” 

 

Chauncey Parker, Director, New York/New Jersey HIDTA

WHAT WE DO

annual report

The ORS Annual Report describes the current state of the overdose epidemic, outlines the program’s key strategies in 2024, and highlights major accomplishments, activities and success stories of our teams. Click on the link below to view the report.

ORS Stories and News

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